Effect of physical rehabilitation on the oxidative modification of proteins in patients with ischemic heart diseases

Abstract

The article presents data on the characteristics of oxidative modification of proteins in patients with coronary heart disease based on a complex restorative treatment. The dynamics of oxidative modification of proteins at a high physical activity before and after the physical rehabilitation was studied. The aim of the study. Study the features of oxidative modification of proteins in patients with ischemic heart disease (IHD) on the background of treatment and assess the dynamic change of proteins at a high physical activity before and after the physical rehabilitation. Materials and methods. The study involved 65 men with ischemic heart disease, stable angina pectoris I-II class, age from 32 to 60 years, averaging 44,6 ± 1,39 years, and 30 men who made up the control group from 36 to 60 years, average 43,0 ± 2,54 years. Results. We found significant alteration index OMP at a high-level exercise in groups II and III, which amounted to respectively 0,9 ± 0,13 OOH (p <0.05) and 0,6 ± 0,04 OOH (p <0.001) compared with controls 0,7 ± 0,05 OOH, with a tendency to increase in the group and where the figure was 0,8 ± 0,20 OOH. Conclusion. 1. In patients with coronary artery disease detected increase in oxidative modification of proteins (p <0.001) positive correlation with the content of creatinine (r = 0,35) (p <0.05) and lactate dehydrogenase activity (r = 0,42) (p <0.05), and negative - of the total activity of creatine phosphokinase (r = -0,54) (p <0.05). After the physical rehabilitation according to our methodology of bicycle training reduced oxidative modification of proteins in the study group with a direct correlation with lactate dehydrogenase activity (r = 0,35) (p <0.05), indicating a decrease in metabolic acidosis and improve cell.