Disorders of the mineral exchange and metabolism of bone tissue as a pathogenetic basis of physical rehabilitation patients with coxartarosis

Abstract

Purpose. The percent of disabled people due to the coxarthrosis of different genesis is varied between 20% and 30% among incapacitated patients, suffered from joints diseases. Material: Aim of the study: to identify the peculiarities of a bone remodeling in relation to the mineral metabolism at the patients with coxarthrosis, including the gender and hormonal adjustment. The study is based on the analysis biochemical parameters in the serum of 57 patients, suffering from coxarthrosis I-II stages. Assessment of the metabolic function of a bone tissue included analysis of mineral homeostasis. Results: The analysis of macroelement metabolism revealed a decreased level of both total calcium fraction on 9.5% and its ionized form on 6.2%. In the women, deficiency of total calcium was observed in 1.9 times more often than in the men, its level was lower on 5.8%. At women in the perimenopausal of climacteric period, ionized calcium deficiency was on 6.0% lower than in the postmenopausal period. Increasing of calcium excretion in urine at the women occurred in 1.8 times more often (94.4%) than at the men (52.4%). Calcium deficiency was accompanied by increase of phosphorus on 24.4%. In the women, these changes were observed twice often than in the men, and phosphorus content was higher on 13.5%. In the perimenopausal period at women, level of phosphorus was higher on 8.7% than in the postmenopausal climacteric period. The results show that negative bone balance and disorders in the mineral metabolism as a whole are interrelated process. Conclusions: Coxarthrosis in the initial stages of development is accompanied by a negative bone balance more than in half of women and a third part of men. Deepening of a calcium-phosphorus imbalance, magnitude changes in magnesium content and decreasing of a bone formation in women increases in the perimenopausal period of hormonal restructuring.