Genetic basis of hemodynamic response to controlled physical activity assessment in the elderly

Abstract

Examining the genetic basis for hemodynamic responses to controlled physical activity in the elderly holds both scientific and practical significance within the realm of physical culture and sports, thereby expanding avenues for further investigation. The primary objective of this study was to assess the correlation between polymorphisms in select metabolic genes and the hemodynamic parameters of elderly individuals, both at rest and following controlled physical activity. The research involved 99 participants aged between 60 and 67, regularly engaging in physical training within a sports and recreation complex. During the initial phase, blood samples were collected from all subjects to analyze polymorphisms in four genes: synaptotagmin (SYT 10, rs6488162), branched-chain amino acid transaminase 1 gene (BCAT 1, rs4963772), a gene responsible for a protein interacting with alpha-synuclein (SNCAIP, rs4836027), and the ubiquinone oxidoreductase A11 subunit gene (NDUFA11, rs12974440). The study of gene polymorphisms was carried out by real-time polymerase chain reaction. At the second stage, all subjects were tested using the six-minute walking technique at the maximum pace. The distance covered was recorded in meters. Before and immediately after the stress testing, the heart rate and the level of systolic and diastolic blood pressure were recorded by noninvasive tonometry. Based on these hemodynamic parameters, the predominant nature of the autonomic nervous system response to dosed physical activity was evaluated. Results. As a result of the research, we found that polymorphisms of metabolic profile genes play an essential role in human body functional response formation. On the one hand, some genotypes of the genes ST 10, BCAT1, SNCAIP and DUFA 11 are involved in determining the nature of the autonomic response to physical activity in the elderly people. On the other hand, the relationship of polymorphisms of most of these genes with both indicators of systemic hemodynamics in a calm state and their dynamics after performing stress testing in the form of a six-minute walk has been established. Conclusions. The established peculiarities of genetic determination and hemodynamic response at rest and after dosed physical activity expand the field of knowledge of this issue. The results obtained can be used in other scientific research in the field of physical culture and sports.